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College football Week 4 picks, predictions

2025 college football Week 4 picks against the spread, odds, lines, key trends: Vegas expert reveals best bets

The Week 4 college football odds board has populated with dozens of games that unfold over the course of Thursday, Friday and Saturday.

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College football Week 4 picks, predictions: SEC, Big Ten clashes lead schedule

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Wisconsin vs. Maryland prediction, odds, time, line: 2025 College Football Week 4 picks

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UConn vs. Ball State Prediction, Odds, Picks - September 20, 2025

The UConn Huskies (1-2) are a massive 21-point favorite heading into their matchup on Saturday, September 20, 2025 against the Ball State Cardinals (1-2).

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Bold predictions for Michigan Football vs Nebraska Cornhuskers

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USC vs. Michigan State prediction, pick, odds for Saturday's NCAA football game - 9/20/2025

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Baylor vs. Arizona State football odds and betting trends | 9/20/2025

The Sun Devils should compete as underdogs (+2.5) in their matchup with the Bears (the game has an over/under of 59.5 points).

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Mississippi State vs. Northern Illinois Prediction, Odds, Picks - September 20, 2025

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USC vs. Michigan State bold predictions for College Football Week 4

ESPN College GameDay 2025 Week 4 Location Hosts, TV Schedule and Predictions

The ESPN College GameDay crew rolls into Miami in Week 4 for the latest in a longtime rivalry between the Hurricanes and the Florida Gators.

2hon MSN

College football Week 4 storylines: Winning doesn't come cheap; new No. 1 QB on NFL Draft boards?

We've all heard it repeated ad nauseam over the years, but it feels especially relevant in this current moment of college football. UCLA and Virginia Tech kicked off the coaching carousel last weekend when they fired their coaches.

1don MSN

Top 3 most intriguing games for NFL Week 3

Week 2 in the NFL would see some quarterbacks go down with injuries. Cincinnati Bengals QB Joe Burrow will be out at least 3 months, Washington Commanders QB Jayden Daniels is day-to-day, Minnesota Vikings QB J.